Characterization of the hyperpolarization-activated inward current in isolated human atrial myocytes
نویسندگان
چکیده
منابع مشابه
Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts.
BACKGROUND The hyperpolarization-activated inward current (I[f]) was found to be overexpressed in hypertrophied rat ventricular myocytes, indicating that I(f) might favor arrhythmias in hypertrophied or failing ventricular myocardium. In the present study, we evaluated whether I(f) is expressed in human ventricular myocardium, if it may be increased in human heart failure, and if its autonomic ...
متن کاملCharacterization of a hyperpolarization-activated inward current in Cajal-Retzius cells in rat neonatal neocortex.
Cajal-Retzius cells are among the first neurons appearing during corticogenesis and play an important role in the establishment of cortical lamination. To characterize the hyperpolarization-activated inward current (I(h)) and to investigate whether I(h) contributes to the relatively positive resting membrane potential (RMP) of these cells, we analyzed the properties of I(h) in visually identifi...
متن کاملHyperpolarization-activated inward current in histaminergic tuberomammillary neurons of the rat hypothalamus.
1. Intracellular recordings were obtained from histaminergic tuberomammillary (TM) neurons of rat hypothalamus in an in vitro slice preparation. The properties of a time- and voltage-dependent inward current activated on hyperpolarization, Ih, were studied by use of the single-electrode voltage-clamp technique. 2. The activation curve of Ih was well fit by a sigmoidal function, with half-maxima...
متن کاملHyperpolarization activated cation current (If) in cardiac myocytes from pulmonary vein sleeves in the canine with atrial fibrillation
OBJECTIVE To investigate the characteristics of ectopic automaticity and cation current (I(f)) of cardiac myocytes from pulmonary vein sleeves (PVs) in canines with atrial fibrillation. METHODS The canines (8-10 years old) were subjected to long-term, rapid atrial pacing (RAP) for 10 weeks, which induced the atrial fibrillation model. Disassociation of PVs of canines yielded single cardiac my...
متن کاملFunction of the hyperpolarization-activated inward rectification in nonmyelinated peripheral rat and human axons.
The function of time-dependent, hyperpolarization-activated inward rectification was analyzed on compound potentials of nonmyelinated axons in the mammalian peripheral nervous system. Isolated rat vagus nerves and fascicles of biopsied human sural nerve were tested in a three-chambered, Vaseline-gap organ bath at 37 degrees C. Inward rectification was assessed by recording the effects of long-l...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1998
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(98)00047-9